Endocrine Abstracts

Background: In the classic paradigm, the primary function of sex hormone-binding globulin (SHBG) was thought to passively bind and transport steroids and estrogens in the blood to access target tissues and to determine their bioavailable fraction. Now there is increasing evidence that SHBG plays an active role in steroid actions and is an actively contributes to many age-associated comorbidities including type 2 diabetes, obesity, and metabolic syndrome (MetS).<p class="ab...

Objective: Although subclinical thyroid dysfunction is associated with cardiac endpoints such as endothelial dysfunction, left ventricular hypertrophy, thickened artery walls or atrial fibrillation, it is currently under debate whether subclinical hyper- or hypothyroidism as well as thyroid function within the reference range are associated with an increased risk of hypertension. So far no study investigated the association between thyroid function and blood pressure in childr...

Objective: In vitro and in vivo models revealed that the somatotropic system exerts central effects on the central nervous system. The objective of this study was to investigate for the first time whether varying endogenous IGF1 levels are associated with mental health outcomes, namely affective disorders, in humans.Design and methods: We included 6773 subjects from the DETECT study, a representative study on primary care patients in German...